Cutaneous Infectivity in Experimental Poliomyelitis
نویسندگان
چکیده
1. Bilateral olfactory neurectomy did not prevent experimental poliomyelitis on intravenous or intracutaneous inoculation. 2. Various operative procedures increased the susceptibility of monkeys to infection with experimental poliomyelitis.
منابع مشابه
Infectivity and Immunity Resulting from the Injection of Poliomyelitis Virus by the Intracutaneous Route
The infectivity of poliomyelitis virus by the intracutaneous route occurs in certain strains but is not a constant character. The inconsistency of skin infectivity tests indicates that there is some property yet unknown which influences this characteristic. Strains of poliomyelitis virus vary in the degree of immunity produced in experimental monkeys injected with active virus by the intracutan...
متن کاملAdaptation of a Lansing Strain of Poliomyelitis Virus to Newborn Mice
By means of rapid serial passages, including 3 successive "blind" passages, the MEF1 strain, a Lansing-type poliomyelitis virus, has been adapted to new-born mice. The virus can readily be propagated in newborn mice, in which fully adapted virus induces in almost all inoculated animals the experimental disease, resulting in a much greater infectivity for the central nervous system and a uniform...
متن کاملThe Intracellular Distribution of Lansing Poliomyelitis Virus in the Central Nervous System of Infected Cotton Rats
A procedure has been described for the centrifugal fractionation of the cellular particulate components of CNS tissue infected with poliomyelitis virus. A study of the distribution of infectivity among these components revealed that approximately four-fifths of the virus is found free in the submicroscopic particle fraction. The validity of the conclusion that the virus is located in this fract...
متن کاملThe Growth Curve of the Lansing Strain of Poliomyelitis Virus in the Central Nervous System of the Mouse
After intracerebral inoculation of mice with a 10 per cent suspension (approximately 2000 LD(50)) of the Lansing strain of poliomyelitis virus, the infectivity titer in the brain decreased for approximately 6 hours. It then rose rapidly for 12 to 18 hours to reach titers of over 10(-4). The rise in titer in the spinal cord closely paralleled that in the brain for 18 hours, after which the titer...
متن کاملThe Growth Curve of the Lansing Strain of Poliomyelitis Virus in Mice: the Effect of Sodium Monofluoroacetate and Methionine Sulfoximine on the Early Phase of Growth of the Virus
The early phase of growth of the Lansing strain of poliomyelitis virus in the mouse brain and cord was suppressed, or delayed, by the intraperitoneal administration of sodium monofluoroacetate in doses of 6 mg./kg. but not of 3 mg./kg. 1 hour before the intracerebral inoculation of virus. There was also a delay in the time at which the first signs of illness appeared in the treated mice. Simila...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- The Journal of Experimental Medicine
دوره 68 شماره
صفحات -
تاریخ انتشار 1938